Clemons K V, Stevens D A
Department of Medicine, Santa Clara Valley Medical Center, San Jose, California 95128, USA.
Antimicrob Agents Chemother. 1995 Mar;39(3):778-80. doi: 10.1128/AAC.39.3.778.
The efficacy of D0870 was studied in a murine model of systemic histoplasmosis and was compared with that of fluconazole. All regimens of D0870 (1 or 10 mg/kg of body weight given daily or 1, 10, or 100 mg/kg given every other day) and 100 mg of fluconazole per kg given daily provided complete protection from lethality. Comparison of the number of viable Histoplasma capsulatum yeasts remaining in the spleen or liver indicated that D0870 was superior to fluconazole in clearing and curing infection. D0870 was 10- to 100-fold more efficacious than fluconazole in the treatment of experimental histoplasmosis.
在系统性组织胞浆菌病的小鼠模型中研究了D0870的疗效，并与氟康唑进行了比较。D0870的所有给药方案（每日给予1或10mg/kg体重或隔日给予1、10或100mg/kg）以及每日给予每千克100mg氟康唑均可提供完全的致死保护。比较脾脏或肝脏中残留的荚膜组织胞浆菌酵母的活菌数量表明，D0870在清除和治愈感染方面优于氟康唑。在治疗实验性组织胞浆菌病方面，D0870的疗效比氟康唑高10至100倍。
