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Mykosen. 1987 Apr;30(4):186-94. doi: 10.1111/j.1439-0507.1987.tb03967.x.

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Fluconazole. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in superficial and systemic mycoses.氟康唑。对其药效学和药代动力学特性以及在浅表和全身性真菌病中的治疗潜力的综述。
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本文引用的文献

1
Fungemia in the immunocompromised host. Changing patterns, antigenemia, high mortality.免疫功能低下宿主的真菌血症。模式改变、抗原血症、高死亡率。
Am J Med. 1981 Sep;71(3):363-70. doi: 10.1016/0002-9343(81)90162-5.
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Medical mycology in crisis.处于危机中的医学真菌学。
J Lab Clin Med. 1983 Nov;102(5):685-93.
3
Candida infections in surgical patients.外科患者的念珠菌感染
Ann Surg. 1983 Jul;198(1):42-7. doi: 10.1097/00000658-198307000-00008.
4
Simple model for the study of Pseudomonas aeruginosa infections in leukopenic mice.用于研究白细胞减少小鼠铜绿假单胞菌感染的简易模型。
Infect Immun. 1983 Mar;39(3):1067-71. doi: 10.1128/iai.39.3.1067-1071.1983.
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In vitro and in vivo comparisons of amphotericin B and N-D-ornithyl amphotericin B methyl ester.两性霉素B与N-D-鸟氨酰两性霉素B甲酯的体外和体内比较
Antimicrob Agents Chemother. 1985 Mar;27(3):302-5. doi: 10.1128/AAC.27.3.302.
6
Activity of fluconazole (UK 49,858) and ketoconazole against Candida albicans in vitro and in vivo.氟康唑（UK 49,858）和酮康唑在体外及体内对白色念珠菌的活性。
Antimicrob Agents Chemother. 1986 Sep;30(3):418-22. doi: 10.1128/AAC.30.3.418.
7
Treatment of cryptococcal meningitis in mice with fluconazole.用氟康唑治疗小鼠隐球菌性脑膜炎。
J Antimicrob Chemother. 1986 Aug;18(2):261-70. doi: 10.1093/jac/18.2.261.
8
Comparison of the in vitro and in vivo activity of the bis-triazole derivative UK 49,858 with that of amphotericin B against Histoplasma capsulatum.双三唑衍生物UK 49,858与两性霉素B对荚膜组织胞浆菌的体外和体内活性比较。
Antimicrob Agents Chemother. 1986 Apr;29(4):660-2. doi: 10.1128/AAC.29.4.660.
9
Pharmacokinetic evaluation of UK-49,858, a metabolically stable triazole antifungal drug, in animals and humans.UK-49858（一种代谢稳定的三唑类抗真菌药物）在动物和人体中的药代动力学评估。
Antimicrob Agents Chemother. 1985 Nov;28(5):648-53. doi: 10.1128/AAC.28.5.648.
10
Efficacy of UK-49,858 (fluconazole) against Candida albicans experimental infections in mice.UK-49858（氟康唑）对小鼠白色念珠菌实验性感染的疗效。
Antimicrob Agents Chemother. 1985 Dec;28(6):815-8. doi: 10.1128/AAC.28.6.815.

氟康唑与两性霉素B治疗免疫抑制小鼠组织胞浆菌病的比较。

Comparison of fluconazole and amphotericin B in treating histoplasmosis in immunosuppressed mice.

作者信息

Kobayashi G S, Travis S J, Medoff G

机构信息

Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri 63110.

出版信息

Antimicrob Agents Chemother. 1987 Dec;31(12):2005-6. doi: 10.1128/AAC.31.12.2005.

DOI:10.1128/AAC.31.12.2005
PMID:2830843
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC175844/
Abstract

Fluconazole (UK-49,858) was compared with amphotericin B in treating histoplasmosis in female AKR mice immunosuppressed with either cyclophosphamide or cortisone. Both drugs protected animals from a lethal challenge with Histoplasma capsulatum, but neither regimen resulted in cures since viable organisms were cultured from spleens of survivors.

摘要

将氟康唑（UK-49,858）与两性霉素B用于治疗用环磷酰胺或可的松免疫抑制的雌性AKR小鼠组织胞浆菌病。两种药物均能保护动物免受荚膜组织胞浆菌的致命攻击，但两种治疗方案均未治愈，因为从存活小鼠的脾脏中培养出了活的病原体。