氟康唑与两性霉素B治疗免疫抑制小鼠组织胞浆菌病的比较。
Comparison of fluconazole and amphotericin B in treating histoplasmosis in immunosuppressed mice.
作者信息
Kobayashi G S, Travis S J, Medoff G
机构信息
Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri 63110.
出版信息
Antimicrob Agents Chemother. 1987 Dec;31(12):2005-6. doi: 10.1128/AAC.31.12.2005.
Abstract
Fluconazole (UK-49,858) was compared with amphotericin B in treating histoplasmosis in female AKR mice immunosuppressed with either cyclophosphamide or cortisone. Both drugs protected animals from a lethal challenge with Histoplasma capsulatum, but neither regimen resulted in cures since viable organisms were cultured from spleens of survivors.
摘要
将氟康唑（UK-49,858）与两性霉素B用于治疗用环磷酰胺或可的松免疫抑制的雌性AKR小鼠组织胞浆菌病。两种药物均能保护动物免受荚膜组织胞浆菌的致命攻击，但两种治疗方案均未治愈，因为从存活小鼠的脾脏中培养出了活的病原体。
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