Treatment of murine histoplasmosis with UK 49,858 (fluconazole).

Fluconazole was compared with ketoconazole and with amphotericin B in treatment of pulmonary histoplasmosis in immunologically intact mice and in congenitally athymic nude mice. Both fluconazole and amphotericin B increased survival and reduced fungal burden in normal mice. All 3 drugs equally prolonged survival of nude mice challenged with Histoplasma capsulatum, and all effectively reduced the fungal burden. Fluconazole may be a useful antifungal drug in treatment of murine histoplasmosis.