McNamara F, Harris M A, Sullivan C E
National SIDS Council David Read Paediatric Sleep Disorders Centre, Royal Alexandra Hospital for Children, Camperdown, New South Wales, Australia.
J Paediatr Child Health. 1995 Apr;31(2):88-94. doi: 10.1111/j.1440-1754.1995.tb00753.x.
We examined the effectiveness of nasal continuous positive airway pressure (CPAP) for treatment of sleep apnoea in infants.
We studied five infants who all had significant central and mixed apnoea and severe sleep fragmentation. Polysomnographic recordings were performed on 2 consecutive nights in these infants. One night was used as a control study and during the second night nasal CPAP was applied throughout the night.
Nasal CPAP significantly reduced apnoea in each infant, with the apnoea index (apnoeas/h) decreasing from 65.6 +/- 14.6 during the control study to 10.5 +/- 14.6 during CPAP in non-rapid eye movement (non-REM) sleep, and from 106 +/- 13.9 during the control study to 26.6 +/- 13.9 during CPAP in REM sleep. Nasal CPAP also improved the sleep fragmentation markedly; REM sleep increased from 14.2 +/- 1.2% of sleep during the control study to 27.1 +/- 1.2% of sleep during CPAP.
We conclude that nasal CPAP is an effective treatment for infantile apnoea. Sleep apnoea in these infants is associated with profound sleep fragmentation, which is reversed by nasal CPAP.
我们研究了经鼻持续气道正压通气（CPAP）治疗婴儿睡眠呼吸暂停的有效性。
我们研究了5名婴儿，他们均有明显的中枢性和混合性呼吸暂停以及严重的睡眠片段化。对这些婴儿连续两晚进行多导睡眠图记录。一晚作为对照研究，另一晚整晚应用经鼻CPAP。
经鼻CPAP显著减少了每个婴儿的呼吸暂停，呼吸暂停指数（呼吸暂停次数/小时）在非快速眼动（非REM）睡眠期间从对照研究时的65.6±14.6降至CPAP期间的10.5±14.6，在REM睡眠期间从对照研究时的106±13.9降至CPAP期间的26.6±13.9。经鼻CPAP还显著改善了睡眠片段化；REM睡眠从对照研究时占睡眠的14.2±1.2%增加到CPAP期间占睡眠的27.1±1.2%。
我们得出结论，经鼻CPAP是治疗婴儿呼吸暂停的有效方法。这些婴儿的睡眠呼吸暂停与严重的睡眠片段化有关，经鼻CPAP可逆转这种情况。
