56例糖尿病患者晶状体自发荧光及血视网膜屏障的荧光光度研究。

Fluorophotometric study of lens autofluorescence and the blood-retinal barrier in 56 diabetic patients.

作者信息

Bordat B, Arnaud C, Guirguis I R, Laudeho A

机构信息

Department of Ophthalmology, Gui de Chauliac Hospital, Montpellier, France.

出版信息

Eur J Ophthalmol. 1995 Jan-Mar;5(1):13-8. doi: 10.1177/112067219500500103.

DOI:10.1177/112067219500500103

PMID:7795396

Abstract

We examined lens autofluorescence and the permeability of the blood-retinal barrier in 56 diabetic patients (34 insulin-dependent and 22 non-insulin-dependent), using the Fluorotron Master (R), a commercially available fluorophotometer. Significant relationships were found between age and lens autofluorescence (p < 0.01), between duration of diabetes and lens autofluorescence in insulin-dependent diabetics (p < 0.01), and between duration of diabetes and blood-retinal barrier permeability in all diabetics (p < 0.05). The relationships between lens autofluorescence and duration of diabetes in non-insulin dependent patients (p > 0.05), and between lens autofluorescence or the penetration ratio and HBA Ic during the five preceding years (p > 0.05) were not significant. Fluorophotometry provides an objective and reproducible method for in vivo investigation of the ocular complications of diabetes and of the factors influencing them.

摘要

我们使用市售的荧光光度计Fluorotron Master (R)，对56例糖尿病患者（34例胰岛素依赖型和22例非胰岛素依赖型）的晶状体自发荧光和血视网膜屏障的通透性进行了检查。结果发现，年龄与晶状体自发荧光之间存在显著相关性（p < 0.01），胰岛素依赖型糖尿病患者的糖尿病病程与晶状体自发荧光之间存在显著相关性（p < 0.01），所有糖尿病患者的糖尿病病程与血视网膜屏障通透性之间存在显著相关性（p < 0.05）。非胰岛素依赖型患者的晶状体自发荧光与糖尿病病程之间的相关性（p > 0.05），以及前五年期间晶状体自发荧光或渗透比与糖化血红蛋白（HBA Ic）之间的相关性（p > 0.05）均不显著。荧光光度法为糖尿病眼部并发症及其影响因素的体内研究提供了一种客观且可重复的方法。