Rønneberg A
Cancer Registry of Norway, Institute of Epidemiological Cancer Research, Oslo.
Occup Environ Med. 1995 Apr;52(4):242-9. doi: 10.1136/oem.52.4.242.
To design a job-exposure matrix for epidemiological studies of men who had worked in a Norwegian aluminium smelter between 1922 and 1975.
Jobs held by cohort members were identified from personnel records. Tasks and their locations were determined for all jobs, and information was gathered about changes in exposure conditions over time. The jobs were combined into categories thought to have experienced similar exposure conditions, and time weighted average exposures were estimated on a relative scale. The results were reviewed by a panel of former smelter employees and an experienced industrial hygienist.
96 different jobs could be identified from the cohort members' work histories. These were grouped into 18 categories, and relative exposure intensities were estimated for 31 different combinations of category and period. The most prevalent exposure in the cohort was pot emissions (fluorides, sulphur dioxide, and carbon monoxide; 74% ever exposed), followed by magnetic fields and heat stress (65-68%), asbestos (40%), and coal tar pitch volatiles (33%).
Although the use of this job-exposure matrix in the subsequent epidemiological studies may result in some misclassification of exposure, this is unlikely to seriously attenuate true risks in a stratified analysis based on cumulative exposure.
为在1922年至1975年间于挪威一家铝冶炼厂工作的男性开展流行病学研究设计一份工作暴露矩阵。
从人事记录中确定队列成员所从事的工作。确定所有工作的任务及其地点,并收集有关暴露条件随时间变化的信息。将这些工作合并为被认为经历了相似暴露条件的类别,并在相对尺度上估计时间加权平均暴露量。结果由一组前冶炼厂员工和一位经验丰富的工业卫生学家进行审查。
从队列成员的工作经历中可识别出96种不同的工作。这些工作被归为18类,并针对类别和时期的31种不同组合估计了相对暴露强度。该队列中最普遍的暴露是电解槽排放物(氟化物、二氧化硫和一氧化碳;74%的人曾暴露于此),其次是磁场和热应激(65 - 68%)、石棉(40%)以及煤焦油沥青挥发物(33%)。
尽管在后续的流行病学研究中使用这份工作暴露矩阵可能会导致暴露的一些错误分类,但在基于累积暴露的分层分析中,这不太可能严重削弱真实风险。