Nave R, Peled R, Lavie P
Sleep Laboratory, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
Eur J Pharmacol. 1995 Mar 6;275(2):213-6. doi: 10.1016/0014-2999(94)00769-4.
Twelve young adults were treated with either melatonin, 3 mg or 6 mg, or placebo, at two different times before an early evening nap (18.00-20.00 h) according to a balanced double-blind Latin square design. Polysomnographic monitoring revealed that both dosages of melatonin significantly shortened sleep latency and increased total sleep time in comparison to placebo, irrespective of the time of administration. Subjects also tended to assess their sleep as 'deeper' after melatonin treatment. Based on previous data and the present results, it was concluded that exogenous melatonin exerts hypnotic effects only when circulating levels of endogenous melatonin are low.
根据平衡双盲拉丁方设计，12名年轻人在傍晚小睡（18:00 - 20:00）前的两个不同时间，分别接受3毫克或6毫克褪黑素或安慰剂治疗。多导睡眠图监测显示，与安慰剂相比，两种剂量的褪黑素均显著缩短了入睡潜伏期并增加了总睡眠时间，且与给药时间无关。受试者在接受褪黑素治疗后也倾向于将自己的睡眠评估为“更深沉”。根据先前的数据和目前的结果，得出的结论是，外源性褪黑素仅在内源性褪黑素循环水平较低时才发挥催眠作用。
