Attenburrow M E, Cowen P J, Sharpley A L
University Department of Psychiatry, Littlemore Hospital, Oxford, UK.
Psychopharmacology (Berl). 1996 Jul;126(2):179-81. doi: 10.1007/BF02246354.
We studied the effects of single evening doses of melatonin (0.3 mg and 1.0 mg orally) on polysomnographically measured sleep in 15 healthy middle-aged volunteers, using a placebo-controlled, double-blind, cross-over design. Compared to placebo, the 1.0 mg dose of melatonin significantly increased Actual Sleep Time, Sleep Efficiency, non-REM Sleep and REM Sleep Latency. These data are consistent with the hypothesis that low dose melatonin has hypnotic effects in humans. It is possible that administered melatonin may have a role to play in the treatment of sleep disorders.
我们采用安慰剂对照、双盲、交叉设计，研究了单次晚间口服褪黑素（0.3毫克和1.0毫克）对15名健康中年志愿者多导睡眠图测量睡眠的影响。与安慰剂相比，1.0毫克剂量的褪黑素显著增加了实际睡眠时间、睡眠效率、非快速眼动睡眠和快速眼动睡眠潜伏期。这些数据与低剂量褪黑素对人类有催眠作用的假设一致。服用的褪黑素可能在睡眠障碍的治疗中发挥作用。
