Yousef M I, Salem M H, Ibrahim H Z, Helmi S, Seehy M A, Bertheussen K
Department of Environmental Studies, University of Alexandria, Egypt.
J Environ Sci Health B. 1995 Jul;30(4):513-34. doi: 10.1080/03601239509372951.
The present study was undertaken to investigate the effect of chronic treatment with two sublethal doses of Carbofuran (carbamate insecticide) and Glyphosate (organophosphorus herbicide) on body weight and semen characteristics in mature male New Zealand white rabbits. Pesticide treatment resulted in a decline in body weight, libido, ejaculate volume, sperm concentration, semen initial fructose and semen osmolality. This was accompanied with increases in the abnormal and dead sperm and semen methylene blue reduction time. The hazardous effect of these pesticides on semen quality continued during the recovery period, and was dose-dependent. These effects on sperm quality may be due to the direct cytotoxic effects of these pesticides on spermatogenesis and/or indirectly via hypothalami-pituitary-testis axis which control the reproductive efficiency.
本研究旨在探讨用两种亚致死剂量的克百威（氨基甲酸酯类杀虫剂）和草甘膦（有机磷除草剂）对成年雄性新西兰白兔进行长期处理后，对其体重和精液特征的影响。农药处理导致体重、性欲、射精量、精子浓度、精液初始果糖含量和精液渗透压下降。同时，异常精子和死精子数量增加，精液亚甲蓝还原时间延长。在恢复期，这些农药对精液质量的有害影响依然存在，且呈剂量依赖性。这些对精子质量的影响可能是由于这些农药对精子发生的直接细胞毒性作用和/或通过控制生殖效率的下丘脑-垂体-睾丸轴间接产生的。
