Mandahl N, Mertens F, Willén H, Rydholm A, Brosjö O, Mitelman F
Department of Clinical Genetics, Lund University Hospital, Sweden.
J Cancer Res Clin Oncol. 1994;120(12):707-11. doi: 10.1007/BF01194267.
Six spindle cell lipomas and two pleomorphic lipomas were analyzed cytogenetically. One spindle cell lipoma had a supernumerary ring chromosome as the sole anomaly. The other five spindle cell lipomas and both pleomorphic lipomas had hypodiploid stemlines with monosomy 16 or unbalanced aberrations leading to loss of 16q13-qter, a feature distinguishing these lipoma subtypes from other benign and borderline adipose tissue tumor histotypes. unbalanced aberrations of chromosomes 13 and 10 were found in five and three cases respectively; 13q12 was lost in all of these cases, whereas there was no common deleted segment in chromosome 10. No aberrations involving 12q13-15, which are frequent in typical lipomas, were found. Both pleomorphic lipomas, but none of the spindle cell lipomas, had hypotetraploid sidelines, multiple nonclonal aberrations, and telomeric associations. The present findings reveal a new cytogenetic/histopathological association in adipose tissue tumors.
对6例梭形细胞脂肪瘤和2例多形性脂肪瘤进行了细胞遗传学分析。1例梭形细胞脂肪瘤有一条额外的环状染色体，为唯一异常。其他5例梭形细胞脂肪瘤和2例多形性脂肪瘤均有亚二倍体干细胞系，伴有16号染色体单体或导致16q13 - qter缺失的不平衡畸变，这一特征将这些脂肪瘤亚型与其他良性和交界性脂肪组织肿瘤组织学类型区分开来。分别在5例和3例中发现了13号和10号染色体的不平衡畸变；所有这些病例中均丢失了13q12，而10号染色体上没有共同的缺失片段。未发现涉及典型脂肪瘤中常见的12q13 - 15的畸变。2例多形性脂肪瘤均有亚四倍体旁系细胞系、多个非克隆性畸变和端粒联合，但梭形细胞脂肪瘤均无。目前的研究结果揭示了脂肪组织肿瘤中一种新的细胞遗传学/组织病理学关联。
