Garry R, Shelley-Jones D, Mooney P, Phillips G
Women's Endoscopic Laser Foundation, South Cleveland Hospital, Middlesbrough, United Kingdom.
Obstet Gynecol. 1995 Jan;85(1):24-9. doi: 10.1016/0029-7844(94)00326-9.
To report the effectiveness and safety of endometrial laser ablation in the treatment of menorrhagia, as determined by detailed follow-up of 600 operations for at least 6 months.
Operative data from 600 endometrial laser ablations performed on 524 women were collected. Five hundred one (96%) of these women were followed with consultations and questionnaires. The mean duration of follow-up was 15 months (range 6-42).
No major operative morbidity occurred. There were no cases of primary or secondary hemorrhage, uterine perforations with the operating instrument, or immediate laparotomy. A successful outcome was reported by 83.4% of patients. A second endometrial laser ablation was required in 14.3% of the women. Success increased with increasing age and low fluid absorption. Cavity length, operation time, duration of follow-up, and whether it was a first or second procedure were not associated with any difference in the success rate, although the hysterectomy rate tended to rise with increasing length of follow-up.
This study, the largest one published from a single institution, with a mean follow-up duration of 15 months, confirms that endometrial laser ablation is a safe and effective treatment for dysfunctional uterine bleeding.
通过对600例手术进行至少6个月的详细随访,报告子宫内膜激光消融术治疗月经过多的有效性和安全性。
收集了对524名女性进行的600例子宫内膜激光消融术的手术数据。其中501名(96%)女性通过咨询和问卷调查进行了随访。平均随访时间为15个月(范围6 - 42个月)。
未发生重大手术并发症。无原发性或继发性出血、手术器械导致的子宫穿孔或立即剖腹手术的病例。83.4%的患者报告治疗成功。14.3%的女性需要进行第二次子宫内膜激光消融术。成功率随着年龄增长和液体吸收量低而增加。宫腔长度、手术时间、随访时间以及手术是首次还是第二次与成功率的差异无关,尽管子宫切除率倾向于随着随访时间的延长而上升。
这项来自单一机构的最大规模研究,平均随访时间为15个月,证实子宫内膜激光消融术是治疗功能失调性子宫出血的一种安全有效的方法。