Wadsworth P F, Jones H B, Cavanagh J B
ZENECA Pharmaceuticals, Macclesfield, Cheshire, UK.
Lab Anim. 1995 Jul;29(3):276-81. doi: 10.1258/002367795781088360.
Whole coronal slices from 6 levels of the brain of 16 cynomolgus monkeys (8 control and 8 treated by daily gavage with a novel pharmaceutical agent for one year) were examined histologically. Mineralized bodies were identified only in coronal sections passing through the optic chiasma and mammillary bodies. Identical mineralized structures were present in the basal ganglia of both control and treated animals. The majority were seen in the globus pallidus, occasionally in the putamen and once in the nearby caudate nucleus. These structures were partially ferruginated and also partially calcified. They appeared to arise in relation to small vessels. They are part of the naturally occurring background pathology of several species of non-human primates and the incidence in this study (3/8 control and 5/8 treated) was approximately what might be expected from reports in the literature. Mineralized bodies of the basal ganglia of primates represent a spontaneous lesion with a characteristic distribution. They may cause confusion in interpretation of toxicological studies if their natural occurrence is not appreciated.
对16只食蟹猴（8只作为对照，8只每天通过灌胃给予一种新型药剂，持续一年）大脑6个层面的整个冠状切片进行了组织学检查。仅在穿过视交叉和乳头体的冠状切片中发现了矿化体。对照动物和经处理动物的基底神经节中均存在相同的矿化结构。大多数见于苍白球，偶尔见于壳核，在附近的尾状核中出现过一次。这些结构部分含铁质沉着，部分钙化。它们似乎与小血管有关。它们是几种非人类灵长类动物自然发生的背景病理学的一部分，本研究中的发生率（3/8对照和5/8经处理）与文献报道中预期的发生率大致相符。灵长类动物基底神经节的矿化体代表一种具有特征性分布的自发性病变。如果不了解其自然发生情况，可能会在毒理学研究的解释中造成混淆。
