Hashimoto T, Tayama M, Murakawa K, Miyazaki M, Yoshimoto T, Harada M, Kuroda Y
Department of Pediatrics, University of Tokushima School of Medicine.
No To Hattatsu. 1994 Nov;26(6):480-5.
Studies of magnetic resonance images have revealed morphological disorders of the brainstem and cerebellum in autistic children and adults. When we studied development of the brainstem and cerebellum in autistic patients, these structures were significantly smaller in autistic patients than in controls. Although the brainstem and cerebellum significantly increased in size with age in both groups, the development of the pons, cerebellar vermis I-V and cerebellar vermis VI-VII was significantly more rapid in autistic patients than in controls. However, the development of the other brain structures in the posterior fossa did not differ between autistic patients and controls. The regression intercepts of the brainstem and cerebellum as well as those of their components were significantly smaller in autistic patients than in controls. These results suggested that significant anatomical changes took place in the posterior fossa brain structures in the prenatal period in autistic children, but were not progressive.
对磁共振图像的研究揭示了自闭症儿童和成人脑干及小脑的形态紊乱。当我们研究自闭症患者脑干和小脑的发育情况时，发现自闭症患者的这些结构明显小于对照组。虽然两组中脑干和小脑的大小都随年龄显著增加，但自闭症患者脑桥、小脑蚓部I - V和小脑蚓部VI - VII的发育速度明显快于对照组。然而，后颅窝其他脑结构的发育在自闭症患者和对照组之间并无差异。自闭症患者脑干和小脑及其各组成部分的回归截距明显小于对照组。这些结果表明，自闭症儿童在产前时期后颅窝脑结构发生了显著的解剖学变化，但并非进行性的。
