Hashimoto T, Tayama M, Murakawa K, Yoshimoto T, Miyazaki M, Harada M, Kuroda Y
University of Tokushima School of Medicine.
J Autism Dev Disord. 1995 Feb;25(1):1-18. doi: 10.1007/BF02178163.
Studies of magnetic resonance images have revealed morphological disorders of the brainstem and cerebellum in autistic children and adults. When we studied development of the brainstem and cerebellum in autistic patients, we found that although the brainstem and cerebellum significantly increased in size with age in both autistic patients and controls, these structures were significantly smaller in autistic patients than in controls. The speed of development of the pons, the cerebellar vermis I-V and the cerebellar vermis VI-VII was significantly more rapid in autistic patients than in the controls. However, the speed of development of the other brain structures in the posterior fossa did not differ between autistic patients and controls. The regression intercepts of the brainstem and cerebellum as well as those of their components were significantly smaller in autistic patients than in controls. Results suggest that brainstem and vermian abnormalities in autism were due to an early insult and hypoplasia rather than to a progressive degenerative process.
对磁共振图像的研究显示，自闭症儿童和成人存在脑干和小脑的形态紊乱。当我们研究自闭症患者脑干和小脑的发育时，我们发现，尽管自闭症患者和对照组的脑干和小脑大小均随年龄显著增加，但自闭症患者的这些结构明显小于对照组。自闭症患者脑桥、小脑蚓部I - V以及小脑蚓部VI - VII的发育速度明显快于对照组。然而，后颅窝其他脑结构的发育速度在自闭症患者和对照组之间并无差异。自闭症患者脑干和小脑及其各组成部分的回归截距明显小于对照组。结果表明，自闭症患者的脑干和蚓部异常是由于早期损伤和发育不全，而非进行性退行性过程所致。
