Akhtari M, McNay D, Mandelkern M, Teeter B, Cline H E, Mallick J, Clark G, Tatar R, Lufkin R, Chan K
Neuromagnetism Laboratory, Hospital of the Good Samaritan, Los Angeles, CA 90017.
Brain Topogr. 1994 Fall;7(1):63-9. doi: 10.1007/BF01184838.
We localized right median nerve somatosensory evoked responses in a normal human subject using an equivalent dipole method applied to magnetic field recordings. High resolution, 3-dimensional MRI data were used to confine source locations to the cortical surface. Results localized in Brodmann area 3b corresponding to location of hand somatosensory cortex derived from direct brain stimulation studies. The solution was unique and total computational time for an exhaustive, brute-force search was small and the results realistic due to applied anatomical constraints. This study demonstrates feasibility of accurate, non-invasive, realistic localization of dynamic human cortical function using spatial constraints provided by MRI images.
我们使用等效偶极子方法对磁场记录进行分析，在一名正常人类受试者中定位右侧正中神经体感诱发电位。利用高分辨率三维磁共振成像（MRI）数据将源位置限定于皮质表面。结果定位于Brodmann 3b区，该区域与直接脑刺激研究得出的手部体感皮层位置相对应。该解决方案是唯一的，对于详尽的强力搜索而言，总计算时间较短，并且由于应用了解剖学限制，结果较为真实。本研究证明了利用MRI图像提供的空间限制对动态人类皮质功能进行准确、无创、真实定位的可行性。
