Sakr W A, Grignon D J, Crissman J D, Heilbrun L K, Cassin B J, Pontes J J, Haas G P
Department of Pathology, Harper Hospital, Detroit, Michigan 48201.
In Vivo. 1994 May-Jun;8(3):439-43.
The relationship of prostatic intraepithelial neoplasia (PIN) and invasive carcinoma of the prostate is not fully understood. It is generally accepted that HGPIN is a probable preinvasive malignant change or at least a marker lesion for carcinoma. The prevalence of HGPIN in younger men is not known. Two hundred and forty nine entirely processed prostates from men aged 20-69 were thoroughly evaluated for the presence of PIN and carcinoma. The histologic diagnosis of all positive cases was confirmed by two pathologists. Our results are summarized as follows: Seventy seven percent of the prostates with HGPIN harbored adenocarcinoma, whereas the frequency of cancer in prostates without HGPIN was 24%. HGPIN was encountered in 0, 5, 10, 41 and 63% of men in the 3rd, 4th, 5th and 7th decades, respectively. The corresponding figures for invasive carcinoma were 2, 29, 32, 55, and 64% respectively.
前列腺上皮内瘤变（PIN）与前列腺浸润癌之间的关系尚未完全明确。一般认为，高级别前列腺上皮内瘤变（HGPIN）可能是一种侵袭前的恶性改变，或者至少是癌的标记性病变。年轻男性中HGPIN的患病率尚不清楚。对249例年龄在20至69岁男性的完整前列腺标本进行了全面评估，以确定是否存在PIN和癌。所有阳性病例的组织学诊断均由两位病理学家确认。我们的结果总结如下：伴有HGPIN的前列腺中77%存在腺癌，而无HGPIN的前列腺中癌的发生率为24%。在第三、第四、第五和第七个十年中，男性HGPIN的发生率分别为0%、5%、10%、41%和63%。侵袭性癌的相应数字分别为2%、29%、32%、55%和64%。
