Troger J, Kieselbach G, Göttinger W, Metzler R, Kähler C, Saria A
Department of Ophthalmology, University of Innsbruck, Austria.
Ger J Ophthalmol. 1994 Aug;3(4-5):245-7.
The pathophysiological events leading to cellular proliferation in proliferative vitreoretinopathy are largely unknown. An involvement of neuropeptides in that disease has recently been discussed, as substance P was found to be highly enriched in the intraocular fluid of patients with proliferative vitreoretinopathy. In the present study, aqueous humor was analyzed for another neuropeptide, vasoactive intestinal polypeptide. Radioimmunoassay revealed significantly increased levels of that polypeptide in the aqueous humor of patients with proliferative vitreoretinopathy as compared with cataract patients who served as controls. As vasoactive intestinal polypeptide contributes to the environment of the retinal pigment epithelial cell layer and induces proliferation of these cells in vitro, this peptide may be involved in the pathogenetic mechanisms leading to cellular proliferation in proliferative vitreoretinopathy.
导致增殖性玻璃体视网膜病变中细胞增殖的病理生理事件在很大程度上尚不清楚。最近有人讨论了神经肽在该疾病中的作用，因为发现P物质在增殖性玻璃体视网膜病变患者的眼内液中高度富集。在本研究中，对房水进行了另一种神经肽——血管活性肠肽的分析。放射免疫分析显示，与作为对照的白内障患者相比，增殖性玻璃体视网膜病变患者房水中该多肽的水平显著升高。由于血管活性肠肽有助于视网膜色素上皮细胞层的微环境，并在体外诱导这些细胞增殖，因此该肽可能参与了导致增殖性玻璃体视网膜病变中细胞增殖的发病机制。
