Meador-Woodruff J H
Department of Psychiatry, University of Michigan, Ann Arbor 48109-0720.
Ann Clin Psychiatry. 1994 Jun;6(2):79-90. doi: 10.3109/10401239409148986.
This paper reviews recent developments in dopamine receptor biology, with an emphasis on our recent understanding of the anatomical locations of where various genes for the dopamine receptors are expressed. At least five genes encoding dopamine receptors have been discovered. These five receptors have distinct pharmacological profiles as well as unique neuroanatomical distributions. While D1 and D2 receptors are widely expressed in many neural systems, the novel D3 and D4 receptors appear to be concentrated within parts of the limbic system, and the D5 receptor has a limited and unusual distribution. The distinct distributions of each of the dopamine receptors in brain facilitates a new understanding of potential neurochemical and neuroanatomical substrates of psychiatric illnesses such as schizophrenia, permits an understanding of observed actions and side effects of psychotropic agents, and provides clues for the rational development of new drugs with effects in the dopaminergic system.
本文综述了多巴胺受体生物学的最新进展，重点阐述了我们近期对多巴胺受体各种基因表达部位的认识。现已发现至少有五个编码多巴胺受体的基因。这五种受体具有不同的药理学特性以及独特的神经解剖分布。虽然D1和D2受体在许多神经系统中广泛表达，但新型的D3和D4受体似乎集中在边缘系统的某些部位，而D5受体的分布有限且不寻常。大脑中每种多巴胺受体的独特分布有助于重新认识诸如精神分裂症等精神疾病潜在的神经化学和神经解剖学基础，有助于理解精神药物已观察到的作用和副作用，并为合理开发作用于多巴胺能系统的新药提供线索。
