Bancroft A J, Else K J, Grencis R K
School of Biological Sciences, University of Manchester, GB.
Eur J Immunol. 1994 Dec;24(12):3113-8. doi: 10.1002/eji.1830241230.
Resistance and susceptibility to the intestinal nematode Trichuris muris has been shown to be dependent upon the induction of T helper type 2 (Th2) or Th1 cells, respectively. This study demonstrates that in a normally resistant strain of mouse, i.e. BALB/K which mounts a dominant Th2 response, sub-threshold levels of infection (< 40 eggs) can survive and become sexually mature adult worms (10-20 adults). The immunological basis of this phenomenon was found to be a dramatically altered polarization of the CD4 response. The Th2-response characteristic of this strain of mouse infected with T. muris was shown to be significantly down-regulated as assessed by in vitro cytokine production [interleukin (IL)-4, IL-5 and IL-9]. In contrast, Th1 parameters of infection such as in vitro interferon-gamma production and the presence of parasite-specific IgG2a were greatly up-regulated in these mice.
对肠道线虫毛首鞭形线虫的抗性和易感性已被证明分别取决于2型辅助性T细胞（Th2）或1型辅助性T细胞（Th1）的诱导。本研究表明，在正常抗性的小鼠品系中，即产生显性Th2反应的BALB/K小鼠中，亚阈值感染水平（<40个虫卵）的寄生虫能够存活并发育成性成熟的成虫（10 - 20条成虫）。这一现象的免疫基础是CD4反应的极化发生了显著改变。通过体外细胞因子产生[白细胞介素（IL）-4、IL-5和IL-9]评估发现，感染毛首鞭形线虫的该品系小鼠的Th2反应特征显著下调。相比之下，这些小鼠感染后的Th1参数，如体外干扰素-γ的产生以及寄生虫特异性IgG2a的存在则大幅上调。
