复发性新型隐球菌性脑膜炎患者的系列新型隐球菌分离株对两性霉素B和氟康唑的敏感性
Susceptibilities of serial Cryptococcus neoformans isolates from patients with recurrent cryptococcal meningitis to amphotericin B and fluconazole.
作者信息
Casadevall A, Spitzer E D, Webb D, Rinaldi M G
机构信息
Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461.
出版信息
Antimicrob Agents Chemother. 1993 Jun;37(6):1383-6. doi: 10.1128/AAC.37.6.1383.
Abstract
Amphotericin B and fluconazole susceptibilities of 13 Cryptococcus neoformans isolates from five patients with recurrent cryptococcal meningitis were determined. For each patient, serial isolates showed no increase in antibiotic resistance relative to the initial isolate. For these patients, recurrent disease was not due to drug resistance but may reflect changes in immune function and/or poor compliance.
摘要
测定了从5例复发性新型隐球菌脑膜炎患者中分离出的13株新型隐球菌对两性霉素B和氟康唑的敏感性。对于每位患者，相对于初始分离株，连续分离株未显示出抗生素耐药性增加。对于这些患者，复发性疾病并非由于耐药性，而是可能反映了免疫功能的变化和/或依从性差。
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