Hammeke T A, Yetkin F Z, Mueller W M, Morris G L, Haughton V M, Rao S M, Binder J R
Department of Neurology, Medical College of Wisconsin, Milwaukee.
Neurosurgery. 1994 Oct;35(4):677-81. doi: 10.1227/00006123-199410000-00014.
Functional magnetic resonance imaging (FMRI) has detected changes in regional cerebral blood flow and volume in response to motor movements, visual stimuli, and auditory stimuli in each of their respective primary cortices. This experiment was conducted to determine whether signal changes in the somatosensory cortex secondary to tactile stimulation could be demonstrated. The palm of the right hand was periodically stimulated while the subject was undergoing echo-planar imaging with a 1.5-T magnetic resonance scanner equipped with local gradient and radio frequency coils. Sagittal and coronal images of 10- to 15-mm slice thickness were selected to include the postcentral gyrus and surrounding regions. Temporally correlated signal changes of 1% to 5% occurred in the peri-rolandic region in each of six subjects. The time course of signal changes was comparable to that found in other primary sensory and motor cortices. The results provide preliminary evidence of the sensitivity of FMRI to activation of the somatosensory cortex with tactile stimulation and support FMRI as a promising noninvasive technique for study of the functional organization and integrity of the cerebrum.
功能磁共振成像（FMRI）已检测到在各自的初级皮层中，响应运动、视觉刺激和听觉刺激时，局部脑血流和血容量的变化。进行该实验是为了确定是否能够证明触觉刺激继发的体感皮层信号变化。在受试者使用配备局部梯度和射频线圈的1.5-T磁共振扫描仪进行回波平面成像时，对其右手手掌进行周期性刺激。选择10至15毫米切片厚度的矢状面和冠状面图像，以包括中央后回及周围区域。六名受试者中，每个受试者的罗兰多周围区域均出现了1%至5%的时间相关信号变化。信号变化的时间过程与在其他初级感觉和运动皮层中发现的情况相当。这些结果为FMRI对触觉刺激激活体感皮层的敏感性提供了初步证据，并支持FMRI作为一种用于研究大脑功能组织和完整性的有前景的非侵入性技术。
