Nakamura T, Kikuchi H, Takebe K, Ishii M, Imamura K, Yamada N, Kudoh K, Terada A
Third Department of Internal Medicine, Hirosaki University School of Medicine, Aomori, Japan.
Pancreas. 1994 Sep;9(5):580-4. doi: 10.1097/00006676-199409000-00007.
Fecal bile acid and fecal fat were determined in 18 normal subjects and 22 patients with chronic pancreatitis, and the relation of fecal bile acid excretion to exocrine pancreatic dysfunction was studied. In chronic pancreatitis fecal bile acid was approximately three times that of control subjects, and large amounts of primary bile acid were detected. A significant correlation between fecal bile acid excretion and bicarbonate secreted from the pancreas was found. This evidence of bile acid malabsorption was not observed until bicarbonate output was < 0.05 mEq/h/kg. A slight correlation between fecal bile acid and absorption rates of fat was demonstrated. These results suggest that bile acid malabsorption observed in chronic pancreatitis is related to an impairment of pancreatic bicarbonate secretion.
对18名正常受试者和22名慢性胰腺炎患者测定了粪便胆汁酸和粪便脂肪，并研究了粪便胆汁酸排泄与胰腺外分泌功能障碍之间的关系。在慢性胰腺炎患者中，粪便胆汁酸约为对照受试者的三倍，且检测到大量的初级胆汁酸。发现粪便胆汁酸排泄与胰腺分泌的碳酸氢盐之间存在显著相关性。直到碳酸氢盐输出量<0.05 mEq/h/kg时，才观察到胆汁酸吸收不良的证据。粪便胆汁酸与脂肪吸收率之间存在轻微相关性。这些结果表明，慢性胰腺炎中观察到的胆汁酸吸收不良与胰腺碳酸氢盐分泌受损有关。
