Virgilio L, Narducci M G, Isobe M, Billips L G, Cooper M D, Croce C M, Russo G
Jefferson Cancer Institute, Jefferson Medical College, Philadelphia, PA 19107.
Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12530-4. doi: 10.1073/pnas.91.26.12530.
The TCL1 locus on chromosome 14q32.1 is frequently involved in chromosomal translocations and inversions with one of the T-cell receptor loci in human T-cell leukemias and lymphomas. The chromosome 14 region translocated or rearranged involves approximately 350 kb of DNA at chromosome band 14q32.1. Within this region we have identified a gene coding for a 1.3-kb transcript, expressed only in restricted subsets of cells within the lymphoid lineage and expressed at high levels in leukemic cells carrying a t(14;14)(q11;q32) chromosome translocation or a inv(14)(q11;q32) chromosome inversion. The cognate cDNA sequence reveals an open reading frame of 342 nt encoding a protein of 14 kDa. The TCL1 gene sequence, which, to our knowledge, shows no sequence homology with other human genes, is preferentially expressed early in T- and B-lymphocyte differentiation.
位于14号染色体q32.1区的TCL1基因座在人类T细胞白血病和淋巴瘤中常与T细胞受体基因座之一发生染色体易位和倒位。发生易位或重排的14号染色体区域涉及14q32.1染色体带约350 kb的DNA。在该区域内，我们鉴定出一个编码1.3 kb转录本的基因，该转录本仅在淋巴谱系内特定的细胞亚群中表达，并且在携带t(14;14)(q11;q32)染色体易位或inv(14)(q11;q32)染色体倒位的白血病细胞中高水平表达。同源cDNA序列显示一个342 nt的开放阅读框，编码一个14 kDa的蛋白质。据我们所知，TCL1基因序列与其他人类基因无序列同源性，在T和B淋巴细胞分化早期优先表达。
