Della Loggia R, Tubaro A, Sosa S, Becker H, Saar S, Isaac O
Istituto di Farmacologia e Farmacognosia, Università di Trieste, Italy.
Planta Med. 1994 Dec;60(6):516-20. doi: 10.1055/s-2006-959562.
By means of a bioassay-oriented fractionation of the CO2 extract of Calendula flowers, the triterpenoids are shown as the most important anti-inflammatory principles of the drug. Among them, the faradiol monoester appears to be the most relevant principle for the activity of the drug, due to its quantitative prevalence. The unesterified faradiol, not present in the extract, is the most active of the tested compounds and equals indomethacin in activity, whereas the monools psi-taraxasterol, lupeol, taraxasterol, and beta-amyrin are less active than the free diol. The anti-inflammatory activity of different CO2 extracts is proportional to their content of faradiol monoester, which can be taken as a suitable parameter for the quality control of Calendula preparations.
通过对金盏花花二氧化碳提取物进行以生物测定为导向的分级分离，三萜类化合物被证明是该药物最重要的抗炎成分。其中，法呢二醇单酯由于其含量优势，似乎是该药物活性的最相关成分。提取物中不存在的未酯化法呢二醇是测试化合物中活性最高的，其活性与消炎痛相当，而单醇类的ψ-蒲公英甾醇、羽扇豆醇、蒲公英甾醇和β-香树脂醇的活性低于游离二醇。不同二氧化碳提取物的抗炎活性与其法呢二醇单酯含量成正比，该含量可作为金盏花制剂质量控制的合适参数。
