使用亚抑菌浓度进行的时间-杀菌协同研究未能预测头孢菌素-利福平联合用药对金黄色葡萄球菌的体内拮抗作用。
Failure of time-kill synergy studies using subinhibitory antimicrobial concentrations to predict in vivo antagonism of cephalosporin-rifampin combinations against Staphylococcus aureus.
作者信息
Brandt C M, Rouse M S, Tallan B M, Wilson W R, Steckelberg J M
机构信息
Infectious Diseases Research Laboratory, Mayo Clinic, Rochester, Minnesota 55905.
出版信息
Antimicrob Agents Chemother. 1994 Sep;38(9):2191-3. doi: 10.1128/AAC.38.9.2191.
Abstract
Results of in vitro time-kill synergy studies using subinhibitory, inhibitory, or suprainhibitory concentrations of bactericidal agents were compared with treatment outcomes of experimental infective endocarditis due to a methicillin-susceptible strain of Staphylococcus aureus. For rifampin-cephalosporin combinations, in vitro synergy testing using recommended fractions of the MIC failed to predict antagonism in vivo while concentrations above the MIC corresponded with antagonism in vivo.
摘要
使用亚抑菌浓度、抑菌浓度或超抑菌浓度的杀菌剂进行体外时间杀菌协同研究的结果，与由甲氧西林敏感金黄色葡萄球菌菌株引起的实验性感染性心内膜炎的治疗结果进行了比较。对于利福平-头孢菌素组合，使用推荐的最低抑菌浓度（MIC）分数进行的体外协同试验未能预测体内的拮抗作用，而高于MIC的浓度与体内的拮抗作用相对应。
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