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1
Failure of time-kill synergy studies using subinhibitory antimicrobial concentrations to predict in vivo antagonism of cephalosporin-rifampin combinations against Staphylococcus aureus.使用亚抑菌浓度进行的时间-杀菌协同研究未能预测头孢菌素-利福平联合用药对金黄色葡萄球菌的体内拮抗作用。
Antimicrob Agents Chemother. 1994 Sep;38(9):2191-3. doi: 10.1128/AAC.38.9.2191.
2
Effective treatment of cephalosporin-rifampin combinations against cryptic methicillin-resistant beta-lactamase-producing coagulase-negative staphylococcal experimental endocarditis.头孢菌素-利福平联合用药对隐匿性产超广谱β-内酰胺酶耐甲氧西林凝固酶阴性葡萄球菌所致实验性心内膜炎的有效治疗
Antimicrob Agents Chemother. 1995 Aug;39(8):1815-9. doi: 10.1128/AAC.39.8.1815.
3
Activities of the combination of quinupristin-dalfopristin with rifampin in vitro and in experimental endocarditis due to Staphylococcus aureus strains with various phenotypes of resistance to macrolide-lincosamide-streptogramin antibiotics.奎奴普丁-达福普汀与利福平联合用药在体外以及针对对大环内酯-林可酰胺-链阳菌素抗生素具有不同耐药表型的金黄色葡萄球菌菌株所致实验性心内膜炎中的活性。
Antimicrob Agents Chemother. 2001 Apr;45(4):1244-8. doi: 10.1128/AAC.45.4.1244-1248.2001.
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Nafcillin-gentamicin synergism in experimental staphylococcal endocarditis.萘夫西林-庆大霉素在实验性葡萄球菌性心内膜炎中的协同作用。
J Lab Clin Med. 1976 Jul;88(1):118-24.
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Antagonism between nafcillin or oxacillin and rifampin against Staphylococcus aureus.萘夫西林或苯唑西林与利福平对金黄色葡萄球菌的拮抗作用。
Antimicrob Agents Chemother. 1982 Nov;22(5):920-2. doi: 10.1128/AAC.22.5.920.
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In vitro and in vivo synergistic activities of linezolid combined with subinhibitory concentrations of imipenem against methicillin-resistant Staphylococcus aureus.利奈唑胺与亚抑菌浓度的亚胺培南联合应用对耐甲氧西林金黄色葡萄球菌的体外和体内协同活性
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Importance of beta-lactamase inactivation in treatment of experimental endocarditis caused by Staphylococcus aureus.
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8
In vitro activity of rifampin alone and in combination with nafcillin and Vancomycin against pathogenic strains of Staphylococcus aureus.利福平单独及与萘夫西林和万古霉素联合对金黄色葡萄球菌致病菌株的体外活性。
Antimicrob Agents Chemother. 1978 May;13(5):759-61. doi: 10.1128/AAC.13.5.759.
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Ampicillin, sulbactam, and rifampin combination treatment of experimental methicillin-resistant Staphylococcus aureus endocarditis in rabbits.氨苄西林、舒巴坦和利福平联合治疗兔实验性耐甲氧西林金黄色葡萄球菌心内膜炎
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Oritavancin Combinations with β-Lactams against Multidrug-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococci.奥利万星与β-内酰胺类药物联合用于对抗耐多药金黄色葡萄球菌和耐万古霉素肠球菌
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Antibiotic synergy against : a systematic review and meta-analysis.抗生素协同作用：一项系统评价与荟萃分析
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In vivo interactions of continuous flucloxacillin infusion and high-dose oral rifampicin in the serum of 15 patients with bone and soft tissue infections due to Staphylococcus aureus - a methodological and pilot study.15例金黄色葡萄球菌引起的骨与软组织感染患者血清中氟氯西林持续输注与大剂量口服利福平的体内相互作用——一项方法学及初步研究
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Rifampin combination therapy for nonmycobacterial infections.利福平联合疗法治疗非分枝杆菌感染。
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Efficacy of linezolid alone or in combination with vancomycin for treatment of experimental endocarditis due to methicillin-resistant Staphylococcus aureus.利奈唑胺单独使用或与万古霉素联合使用治疗耐甲氧西林金黄色葡萄球菌所致实验性心内膜炎的疗效。
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Efficacy of levofloxacin for experimental aortic-valve endocarditis in rabbits infected with viridans group streptococcus or Staphylococcus aureus.左氧氟沙星对感染草绿色链球菌或金黄色葡萄球菌的兔实验性主动脉瓣心内膜炎的疗效。
Antimicrob Agents Chemother. 1999 Nov;43(11):2742-6. doi: 10.1128/AAC.43.11.2742.
6
Effective treatment of cephalosporin-rifampin combinations against cryptic methicillin-resistant beta-lactamase-producing coagulase-negative staphylococcal experimental endocarditis.头孢菌素-利福平联合用药对隐匿性产超广谱β-内酰胺酶耐甲氧西林凝固酶阴性葡萄球菌所致实验性心内膜炎的有效治疗
Antimicrob Agents Chemother. 1995 Aug;39(8):1815-9. doi: 10.1128/AAC.39.8.1815.

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Relative efficacies of broad-spectrum cephalosporins for treatment of methicillin-susceptible Staphylococcus aureus experimental infective endocarditis.广谱头孢菌素治疗甲氧西林敏感金黄色葡萄球菌实验性感染性心内膜炎的相对疗效
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Activity of twenty-one antimicrobial agents including l-ofloxacin against quinolone-sensitive and -resistant, and methicillin-sensitive and -resistant Staphylococcus aureus.
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Antistaphylococcal activity of rifampin with other antibiotics.利福平与其他抗生素的抗葡萄球菌活性。
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Experimental endocarditis I. Staphylococcal endocarditis in rabbits resulting from placement of a polyethylene catheter in the right side of the heart.实验性心内膜炎I. 因在兔心脏右侧放置聚乙烯导管而导致的葡萄球菌性心内膜炎。
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Comparison of the antibacterial activity of rifampicin and other antibiotics.利福平与其他抗生素抗菌活性的比较。
Am J Med Sci. 1968 Oct;256(4):255-65. doi: 10.1097/00000441-196810000-00007.
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Efficacy of vancomycin plus rifampin in experimental aortic-valve endocarditis due to methicillin-resistant Staphylococcus aureus: in vitro-in vivo correlations.万古霉素联合利福平治疗耐甲氧西林金黄色葡萄球菌所致实验性主动脉瓣心内膜炎的疗效：体内外相关性
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Statistical considerations for performing multiple tests in a single experiment. 2. Comparisons among several therapies.
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Comparative in-vitro activities of teicoplanin, vancomycin, coumermycin and ciprofloxacin, alone and in combination with rifampicin or LM 427, against Staphylococcus aureus.替考拉宁、万古霉素、香豆霉素和环丙沙星单独及与利福平或LM 427联合应用对金黄色葡萄球菌的体外比较活性。
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In-vitro activity of vancomycin, teicoplanin, daptomycin, ramoplanin, MDL 62873 and other agents against staphylococci, enterococci and Clostridium difficile.万古霉素、替考拉宁、达托霉素、雷莫拉宁、MDL 62873及其他药物对葡萄球菌、肠球菌和艰难梭菌的体外活性。
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Antimicrobial therapy of experimental endocarditis caused by Staphylococcus aureus.金黄色葡萄球菌所致实验性心内膜炎的抗菌治疗
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使用亚抑菌浓度进行的时间-杀菌协同研究未能预测头孢菌素-利福平联合用药对金黄色葡萄球菌的体内拮抗作用。

Failure of time-kill synergy studies using subinhibitory antimicrobial concentrations to predict in vivo antagonism of cephalosporin-rifampin combinations against Staphylococcus aureus.

作者信息

Brandt C M, Rouse M S, Tallan B M, Wilson W R, Steckelberg J M

机构信息

Infectious Diseases Research Laboratory, Mayo Clinic, Rochester, Minnesota 55905.

出版信息

Antimicrob Agents Chemother. 1994 Sep;38(9):2191-3. doi: 10.1128/AAC.38.9.2191.

DOI:10.1128/AAC.38.9.2191
PMID:7811044
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC284709/
Abstract

Results of in vitro time-kill synergy studies using subinhibitory, inhibitory, or suprainhibitory concentrations of bactericidal agents were compared with treatment outcomes of experimental infective endocarditis due to a methicillin-susceptible strain of Staphylococcus aureus. For rifampin-cephalosporin combinations, in vitro synergy testing using recommended fractions of the MIC failed to predict antagonism in vivo while concentrations above the MIC corresponded with antagonism in vivo.

摘要

使用亚抑菌浓度、抑菌浓度或超抑菌浓度的杀菌剂进行体外时间杀菌协同研究的结果，与由甲氧西林敏感金黄色葡萄球菌菌株引起的实验性感染性心内膜炎的治疗结果进行了比较。对于利福平-头孢菌素组合，使用推荐的最低抑菌浓度（MIC）分数进行的体外协同试验未能预测体内的拮抗作用，而高于MIC的浓度与体内的拮抗作用相对应。