新型咪唑类抗真菌药拉诺康唑对豚鼠实验性皮肤念珠菌病的治疗效果
Therapeutic efficacy of lanoconazole, a new imidazole antimycotic agent, for experimental cutaneous candidiasis in guinea pigs.
作者信息
Niwano Y, Seo A, Kanai K, Hamaguchi H, Uchida K, Yamaguchi H
机构信息
Pharmaceutical Research Institute, Nihon Nohyaku Co., Ltd., Osaka, Japan.
出版信息
Antimicrob Agents Chemother. 1994 Sep;38(9):2204-6. doi: 10.1128/AAC.38.9.2204.
Abstract
The therapeutic efficacy of 1% cream and 1% solution of lanoconazole, a new imidazole antimycotic agent, in the model of cutaneous candidiasis in prednisolone-treated guinea pigs was evaluated in comparison with that of comparable formulations of bifonazole. Each preparation was topically applied once a day for 3 consecutive days, starting on the fifth day postinfection, and quantitative culture study wsa conducted on the ninth day postinfection. Both formulations of lanoconazole were much more highly effective in terms of eradication of fungi than the bifonazole formulations.
摘要
将新型咪唑类抗真菌药拉诺康唑的1%乳膏和1%溶液，与联苯苄唑的同类制剂相比较，评估其对经泼尼松龙治疗的豚鼠皮肤念珠菌病模型的治疗效果。每种制剂从感染后第5天开始，连续3天每天局部用药1次，在感染后第9天进行定量培养研究。就根除真菌而言，拉诺康唑的两种制剂比联苯苄唑制剂的疗效要好得多。
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