Hunt C, Chakravorty N K, Annan G, Habibzadeh N, Schorah C J
Food & Nutrition Department, Huddersfield University.
Int J Vitam Nutr Res. 1994;64(3):212-9.
A randomised double-blind trial involving vitamin C/placebo supplementation was conducted on 57 elderly patients admitted to hospital with acute respiratory infections (bronchitis and bronchopneumonia). Patients were assessed clinically and biochemically on admission and again at 2 and 4 weeks after admission having received either 200 mg vitamin C per day, or placebo. This relatively modest oral dose led to a significant increase in plasma and white cell vitamin C concentration even in the presence of acute respiratory infection. Using a clinical scoring system based on major symptoms of the respiratory condition, patients supplemented with the vitamin fared significantly better than those on placebo. This was particularly the case for those commencing the trial most severely ill, many of whom had very low plasma and white cell vitamin C concentrations on admission. Various mechanisms by which vitamin C could assist this type of patient are discussed.
对57名因急性呼吸道感染（支气管炎和支气管肺炎）入院的老年患者进行了一项涉及补充维生素C/安慰剂的随机双盲试验。患者在入院时以及入院后2周和4周接受每天200毫克维生素C或安慰剂治疗后，进行了临床和生化评估。即使在存在急性呼吸道感染的情况下，这种相对适度的口服剂量也导致血浆和白细胞维生素C浓度显著增加。使用基于呼吸道疾病主要症状的临床评分系统，补充维生素的患者比服用安慰剂的患者情况明显更好。对于那些开始试验时病情最严重的患者尤其如此，他们中的许多人入院时血浆和白细胞维生素C浓度非常低。文中讨论了维生素C可以帮助这类患者的各种机制。
