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对7年间收集的南美7型腺病毒毒株进行的基因组分析。

Genome analysis of South American adenovirus strains of serotype 7 collected over a 7-year period.

作者信息

Kajon A, Wadell G

机构信息

Department of Virology, University of Umeå, Sweden.

出版信息

J Clin Microbiol. 1994 Sep;32(9):2321-3. doi: 10.1128/jcm.32.9.2321-2323.1994.

DOI:10.1128/jcm.32.9.2321-2323.1994
PMID:7814570
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC263996/
Abstract

DNA restriction analysis was carried out on a sample of 212 epidemiologically unrelated adenovirus (Ad) strains of serotype 7 isolated in Chile, Uruguay, and Argentina from nasopharyngeal aspirates of children with acute lower respiratory disease between 1984 and 1990. The identified genome types were Ad7b (n = 12), Ad7c (n = 21), and Ad7h (n = 179). The analysis of the occurrence of the three genome types throughout the study period revealed that Ad7c was the predominant virulent variant in 1984 and indicated that a shift to genome type 7h took place in 1986. Ad7b cocirculated with the other genomic variants at a relatively low frequence.

摘要

对1984年至1990年间从智利、乌拉圭和阿根廷患有急性下呼吸道疾病儿童的鼻咽抽吸物中分离出的212株血清型7的腺病毒（Ad）菌株样本进行了DNA限制性分析，这些菌株在流行病学上无关联。鉴定出的基因组类型为Ad7b（n = 12）、Ad7c（n = 21）和Ad7h（n = 179）。对整个研究期间三种基因组类型出现情况的分析表明，Ad7c在1984年是主要的致病变体，并表明在1986年向基因组类型7h发生了转变。Ad7b与其他基因组变体以相对较低的频率共同流行。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d04/263996/49336d342845/jcm00009-0298-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d04/263996/85caa9e33b98/jcm00009-0297-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d04/263996/3e538f55838c/jcm00009-0298-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d04/263996/49336d342845/jcm00009-0298-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d04/263996/85caa9e33b98/jcm00009-0297-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d04/263996/3e538f55838c/jcm00009-0298-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d04/263996/49336d342845/jcm00009-0298-b.jpg

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