Stephensen C B, Park J Y, Blount S R
Department of International Health, School of Public Health, University of Alabama at Birmingham 35294.
J Virol. 1995 Feb;69(2):1349-52. doi: 10.1128/JVI.69.2.1349-1352.1995.
Callitrichid hepatitis is an infection of New World primates caused by an arenavirus, currently referred to as callitrichid hepatitis virus, that is closely related to lymphocytic choriomeningitis virus (LCMV). We have cloned and sequenced the GP-C gene of callitrichid hepatitis virus and found that the cDNA sequence is 84 to 86% identical to those of the GP-C genes of LCMV strains Armstrong and WE, while the deduced amino acid sequence is 95 to 96% identical to those of the GP-C gene products of the same strains. This high degree of similarity indicates that the etiologic agent of callitrichid hepatitis is in fact LCMV. The wide geographic distribution of callitrichid hepatitis outbreaks in the United States serves as a reminder that LCMV is also a human pathogen whose public health implications are not well understood.
绢毛猴肝炎是由一种沙粒病毒引起的新大陆灵长类动物感染，该病毒目前被称为绢毛猴肝炎病毒，与淋巴细胞性脉络丛脑膜炎病毒（LCMV）密切相关。我们克隆并测序了绢毛猴肝炎病毒的GP-C基因，发现其cDNA序列与LCMV毒株阿姆斯特朗株和WE株的GP-C基因序列有84%至86%的同一性，而推导的氨基酸序列与相同毒株的GP-C基因产物有95%至96%的同一性。这种高度相似性表明，绢毛猴肝炎的病原体实际上是LCMV。美国绢毛猴肝炎疫情的广泛地理分布提醒人们，LCMV也是一种人类病原体，其对公共卫生的影响尚未得到充分了解。
