Suzuki K
Department of Anesthesiology, School of Medicine, Iwate Medical University, Morioka.
Masui. 1994 Oct;43(10):1493-505.
Effects of oxygen inhalation on hemopoiesis were investigated in mice and following results were obtained. 1) The numbers of pluripotent hemopoietic stem cells (CFU-S) and granulocyte-macrophage progenitor cells (GM-CFC) in murine bone marrow and spleen decreased significantly from day 1 of exposure to 70% and 100% oxygen. 2) The numbers of CFU-S and GM-CFC did not recover in mice that were exposed to 100% oxygen for 1 and 2 days followed by air exposure for 7 days. These results suggest that inhalation of more than 70% oxygen for 1 day induces inhibitory effects of the hemopoietic stem cells, and 100% oxygen exposure over 1 day can cause irreversible damage to the hemopoiesis.
在小鼠中研究了吸氧对造血的影响，并获得了以下结果。1）从暴露于70%和100%氧气的第1天起，小鼠骨髓和脾脏中多能造血干细胞（CFU-S）和粒细胞-巨噬细胞祖细胞（GM-CFC）的数量显著减少。2）暴露于100%氧气1天和2天，然后暴露于空气7天的小鼠中，CFU-S和GM-CFC的数量没有恢复。这些结果表明，吸入超过70%的氧气1天会诱导造血干细胞产生抑制作用，而暴露于100%氧气超过1天会对造血造成不可逆的损害。
