Vrielink H, van der Poel C L, Reesink H W, Zaaijer H L, Scholten E, Kremer L C, Cuypers H T, Lelie P N, van Oers M H
Red Cross Blood Bank, Amsterdam, Netherlands.
Lancet. 1995 Jan 14;345(8942):95-6. doi: 10.1016/s0140-6736(95)90063-2.
The infectivity of blood components from donors who were later found to be anti-HCV ELISA-positive was investigated in recipients who were enrolled in a look-back programme. Recipients received ELISA-positive blood components from donors who were PCR-positive and/or RIBA-2-positive (n = 22, group A) or PCR-negative and indeterminate or negative on RIBA-2 (n = 105, group B). 26 of 32 (81%) recipients of group A donors and none of 140 of group B were HCV-infected. All stored serum samples of previous donations (n = 172) of group A donors were anti-HCV-positive in RIBA-3, indicating a chronic carrier state of HCV in these donors.
在参加追溯计划的受血者中，对后来被发现抗丙型肝炎病毒酶联免疫吸附测定（ELISA）呈阳性的献血者的血液成分的传染性进行了调查。受血者接受了来自PCR呈阳性和/或重组免疫印迹法2（RIBA-2）呈阳性的献血者的ELISA阳性血液成分（n = 22，A组），或来自PCR呈阴性且RIBA-2结果不确定或呈阴性的献血者的血液成分（n = 105，B组）。A组献血者的32名受血者中有26名（81%）感染了丙型肝炎病毒，而B组的140名受血者中无一例感染。A组献血者之前所有储存的血清样本（n = 172）在RIBA-3检测中均为抗丙型肝炎病毒阳性，表明这些献血者处于丙型肝炎病毒慢性携带状态。
