Neilson J R, Harrison P, Skidmore S J, King J A, Collingham K E, Milligan D W
Department of Haematology, Birmingham Heartlands Hospital.
J Clin Pathol. 1996 Mar;49(3):230-32. doi: 10.1136/jcp.49.3.230.
To investigate the impact of hepatitis C virus (HCV) infection in long term survivors of haematological malignancy treated before the introduction of blood donor screening in September 1991.
Patients were tested for evidence of HCV infection by third generation enzyme linked immunosorbent assays, a recombinant immunoblot assay and reverse transcriptase polymerase chain reaction. Serum aspartate aminotransferase activities were measured. The number and type of blood component units received by each patient were recorded.
Forty two patients were studied who had received a total of 7143 blood component units. Two patients (4.8%) were found to have HCV infection, both had histological evidence of chronic active hepatitis, and one is now receiving treatment with alpha-interferon. Both of these patients had been missed by the ongoing look-back programme which aims to detect recipients of all known HCV infected blood components.
Although HCV infection affects a minority of long term survivors of haematological malignancy, infected patients may benefit from alpha-interferon treatment. The screening of all patients treated for haematological malignancy before September 1991 is advocated.
调查1991年9月实施献血者筛查之前接受治疗的血液系统恶性肿瘤长期存活者中丙型肝炎病毒（HCV）感染的影响。
采用第三代酶联免疫吸附试验、重组免疫印迹试验和逆转录聚合酶链反应检测患者是否有HCV感染证据。测定血清天冬氨酸转氨酶活性。记录每位患者接受的血液成分单位数量和类型。
研究了42例患者，他们共接受了7143个血液成分单位。发现2例患者（4.8%）感染HCV，二者均有慢性活动性肝炎的组织学证据，其中1例目前正在接受α-干扰素治疗。正在进行的旨在检测所有已知HCV感染血液成分接受者的追溯计划遗漏了这2例患者。
虽然HCV感染影响少数血液系统恶性肿瘤长期存活者，但感染患者可能从α-干扰素治疗中获益。提倡对1991年9月之前接受血液系统恶性肿瘤治疗的所有患者进行筛查。
