Nitta H, Matsumoto K, Shimizu M, Ni X H, Watanabe H
Division of Pharmacology, Research Institute for Wakan-Yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University, Japan.
Biol Pharm Bull. 1995 Sep;18(9):1286-8. doi: 10.1248/bpb.18.1286.
The effect of Panax ginseng extract on the learning performance of aged Fischer 344 rats using the 8-arm radial maze task and the operant discrimination task was examined. Aged rats showed significantly impaired learning performance in both tasks. Daily administration of ginseng extract (8 g/kg/d, p.o. for 12-33 d) ameliorated the impairment of learning performance in the radial maze task but not in the operant discrimination task. These results suggest that subchronic treatment with ginseng extract improves spatial cognitive impairment in aged rats.
研究了人参提取物对老年Fischer 344大鼠在八臂放射状迷宫任务和操作性辨别任务中的学习表现的影响。老年大鼠在这两项任务中均表现出明显的学习能力受损。每日给予人参提取物（8克/千克/天，口服，持续12 - 33天）改善了放射状迷宫任务中的学习能力损伤，但在操作性辨别任务中没有效果。这些结果表明，人参提取物的亚慢性治疗可改善老年大鼠的空间认知障碍。
