Mistríková J, Remenová A, Lesso J, Stanceková M
Department of Microbiology and Virology, Faculty of Natural Sciences, Comenius University, Bratislava, Slovak Republic.
Acta Virol. 1994 Jun;38(3):151-6.
After intranasal inoculation of murine herpesvirus 72 (MHV-72) to Balb/c mice the virus persisted in adherent lung mononuclear cells (AMC). Infectious virus was occasionally detected during a period of eight months after infection in lymphatic organs (thymus, spleen, lymph nodes), bone marrow, alveolar and peritoneal AMC, and lymphocytes and macrophages of peripheral blood by indirect immunofluorescence and cocultivation with permissive VERO cells. Mouse B-cell lines NS0 and SP2/0 were permissive for MHV-72 infection when inoculated in vitro. Virus-neutralizing antibodies have been detected during one year period in the sera of infected mice, and their levels correlated with activation of the latent MHV-72.
将鼠疱疹病毒72（MHV - 72）经鼻内接种到Balb/c小鼠后，病毒在贴壁肺单核细胞（AMC）中持续存在。通过间接免疫荧光以及与敏感的VERO细胞共培养，在感染后的八个月期间，偶尔能在淋巴器官（胸腺、脾脏、淋巴结）、骨髓、肺泡和腹膜AMC以及外周血的淋巴细胞和巨噬细胞中检测到感染性病毒。小鼠B细胞系NS0和SP2/0在体外接种时对MHV - 72感染敏感。在感染小鼠的血清中，一年内均可检测到病毒中和抗体，其水平与潜伏的MHV - 72的激活相关。
