Schlaifer D, Rigal-Huguet F, Robert A, Attal M, Abbal M, Fonck Y, Laurent G, Pris J, Delsol G, Brousset P
Service d'Hématologie, Hôpital de Purpan, Toulouse, France.
Br J Haematol. 1994 Nov;88(3):636-8. doi: 10.1111/j.1365-2141.1994.tb05089.x.
Hodgkin's disease (HD) has been found to be linked to Epstein-Barr virus (EBV). Familial HD (FHD) may be related to a possible unknown agent. We have determined whether EBV small RNAs (EBERs) were found in Reed-Sternberg cells from FHD. Five families were studied for histological subtype and EBER presence. There was a striking similarity in FHD subtypes of each family and 3/11 (27%) of the cases were EBER positive. In conclusion, EBV EBERs are only infrequently found in FHD and other factors including viruses different from EBV should be further investigated in FHD.
