1980 - 1991年英国儿童癌症的基于人群的生存率。
Population based survival rates for childhood cancer in Britain, 1980-91.
作者信息
Stiller C A
机构信息
Department of Paediatrics, University of Oxford.
出版信息
BMJ. 1994 Dec 17;309(6969):1612-6. doi: 10.1136/bmj.309.6969.1612.
OBJECTIVES
To investigate the survival of children with cancer diagnosed during 1980-91 in order to assess the impact of developments in medical care on a population basis.
DESIGN
Retrospective cohort study.
SETTING
Great Britain.
SUBJECTS
14973 children with cancer diagnosed during 1980-91 and included in the population based National Registry of Childhood Tumours.
MAIN OUTCOME MEASURES
Actuarial survival rates.
RESULTS
For all cancers combined, two year survival increased from 66% to 76% between 1980-2 and 1989-91, and five year survival increased from 57% to 65% between 1980-2 and 1986-8. Significant increases in survival rates occurred among children with acute lymphoblastic leukaemia, acute nonlymphocytic leukaemia, retinoblastoma, osteosarcoma, Ewing's sarcoma, rhabdomyosarcoma, and malignant gonadal germ cell tumours. No trend in survival was seen for children with Hodgkin's disease, central nervous system tumours, neuroblastoma, or Wilms's tumour.
CONCLUSIONS
Nearly two thirds of children who have cancer diagnosed can now expect to survive at least 10 years.
目的
调查1980 - 1991年间确诊的癌症患儿的生存率，以便在人群基础上评估医疗发展的影响。
设计
回顾性队列研究。
地点
英国。
研究对象
1980 - 1991年间确诊且纳入基于人群的国家儿童肿瘤登记处的14973名癌症患儿。
主要观察指标
精算生存率。
结果
对于所有癌症综合来看，1980 - 1982年至1989 - 1991年间，两年生存率从66%提高到76%，1980 - 1982年至1986 - 1988年间，五年生存率从57%提高到65%。急性淋巴细胞白血病、急性非淋巴细胞白血病、视网膜母细胞瘤、骨肉瘤、尤因肉瘤、横纹肌肉瘤和恶性性腺生殖细胞肿瘤患儿的生存率显著提高。霍奇金病、中枢神经系统肿瘤、神经母细胞瘤或肾母细胞瘤患儿的生存率未见趋势变化。
结论
现在，近三分之二被诊断患有癌症的儿童有望存活至少10年。
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