Birch J M, Marsden H B, Jones P H, Pearson D, Blair V
University of Manchester.
Br Med J (Clin Res Ed). 1988 May 14;296(6633):1372-6. doi: 10.1136/bmj.296.6633.1372.
Survival from cancer of children whose cancer was diagnosed during the 30 years 1954-83 was analysed. The study was population based with nearly 3000 cases covering about 30 million child years at risk. When survival during the three decades 1954-63, 1964-73, and 1974-83 was compared striking improvements were observed. For all childhood cancer five year survival increased from 21% in the first decade to 49% in the third decade. During the first and third decades five year survival rates for acute lymphocytic leukaemia increased from 2% to 47%, Hodgkin's disease from 44% to 91%, non-Hodgkin's lymphoma from 18% to 45%, Wilms's tumour from 31% to 85%, and germ cell tumours from 10% to 64%. Twenty patients developed second primary tumours, but otherwise there were few late deaths. Less than 1% of children who survived without a relapse for 10 years subsequently died of their initial cancer. Survival from childhood cancer is no longer rare, and people who have been cured of cancer during childhood should be accepted as normal members of society.
对1954年至1983年这30年间被诊断患有癌症的儿童的癌症生存率进行了分析。该研究基于人群，有近3000例病例，涵盖约3000万儿童年的风险期。比较1954 - 1963年、1964 - 1973年和1974 - 83年这三个十年期间的生存率时，观察到了显著改善。对于所有儿童癌症，五年生存率从第一个十年的21%提高到了第三个十年的49%。在第一个和第三个十年期间，急性淋巴细胞白血病的五年生存率从2%提高到了47%，霍奇金病从44%提高到了91%，非霍奇金淋巴瘤从18%提高到了45%，肾母细胞瘤从31%提高到了85%，生殖细胞瘤从10%提高到了64%。20名患者发生了第二原发性肿瘤，但除此之外晚期死亡很少。在10年无复发存活的儿童中，不到1%随后死于其初始癌症。儿童癌症的生存不再罕见，童年时期患癌已治愈的人应被视为社会的正常成员。
