Kubo K, Aoki H, Nanba H
Yukiguni Maitake Co., Ltd. Niigata, Japan.
Biol Pharm Bull. 1994 Aug;17(8):1106-10. doi: 10.1248/bpb.17.1106.
The fruit body of Grifola frondosa (maitake), Basidiomycetes was confirmed to contain substances with anti-diabetic activity. When 1 g/d of powdered fruit body of maitake was given orally to a genetically diabetic mouse (KK-Ay), blood glucose reduction was observed, in contrast to the control group in which the blood glucose increased with ageing. Moreover, levels of insulin and triglyceride in plasma demonstrated a change similar to blood glucose with feeding of maitake. Ether-ethanol-soluble (ES) and hot water-soluble (WS) fractions were prepared from the fruit body and their hypoglycemic activity was examined. Blood glucose-lowering activity was found when ES-fraction or WS-50% ethanol float (X) fraction was administered orally, but other WS-fractions were inactive. These results suggest that the anti-diabetic activity was present not only in the ES-fraction consisting of lipid but also in the X-fraction of peptidoglycan (sugar:protein = 65:35).
灰树花（舞茸）子实体，担子菌纲，被证实含有具有抗糖尿病活性的物质。当给遗传性糖尿病小鼠（KK-Ay）口服1克/天的灰树花粉末子实体时，观察到血糖降低，而对照组血糖随年龄增长而升高。此外，喂食灰树花后，血浆中胰岛素和甘油三酯水平呈现出与血糖类似的变化。从子实体中制备了乙醚-乙醇可溶性（ES）和热水可溶性（WS）组分，并检测了它们的降血糖活性。口服ES组分或WS-50%乙醇漂浮物（X）组分时发现有降血糖活性，但其他WS组分无活性。这些结果表明，抗糖尿病活性不仅存在于由脂质组成的ES组分中，也存在于肽聚糖的X组分中（糖：蛋白质 = 65:35）。
