Gould T J, Chadman K, Bickford P C
Institute for Behavioral Genetics, University of Colorado, Boulder 80309, USA.
Neurosci Lett. 1998 Jul 10;250(3):165-8. doi: 10.1016/s0304-3940(98)00477-7.
We examined whether a 2-week treatment with the spin-trapping agent MDL 101.002 (MDL) or a diet supplemented with vitamin E (Vit E) would alleviate age-related deficits in cerebellar noradrenergic function of male 18-20 month old F344 rats compared to age-matched controls. Cerebellar beta-adrenergic receptor function was assessed using extracellular recordings of Purkinje cells during iontophoresis of GABA and isoproterenol (ISO). Noradrenergic receptor function of MDL and Vit E-treated rats was similar to young rats whereas for non-treated rats it was typical of that previously recorded in aged rats. Thus, treatment with MDL or Vit E reverses age-related deficits in cerebellar noradrenergic receptor function.
我们研究了与年龄匹配的对照组相比，用自旋捕捉剂MDL 101.002（MDL）进行为期2周的治疗或补充维生素E（Vit E）的饮食是否能减轻18 - 20月龄雄性F344大鼠小脑去甲肾上腺素能功能的年龄相关缺陷。在GABA和异丙肾上腺素（ISO）离子导入期间，通过浦肯野细胞的细胞外记录来评估小脑β-肾上腺素能受体功能。MDL和Vit E处理组大鼠的去甲肾上腺素能受体功能与年轻大鼠相似，而未处理组大鼠的功能则是先前在老年大鼠中记录到的典型功能。因此，MDL或Vit E治疗可逆转小脑去甲肾上腺素能受体功能的年龄相关缺陷。
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