Shaw N J, McIvor L
Neonatal Intensive Care Unit, Fazakerley Hospital, Liverpool.
Arch Dis Child Fetal Neonatal Ed. 1994 Nov;71(3):F203-5. doi: 10.1136/fn.71.3.f203.
Thirty two infants born to mothers taking methadone and 32 matched controls were studied to determine the incidence, timing, and frequency of persistence of withdrawal signs in infants born to maternal methadone users. Twelve (37%) infants received treatment for symptoms of withdrawal. The median length of time from birth to initiation of treatment was 23 hours (range 15-64 hours), the median length of treatment was six days (range 1-22 days). In the first six weeks after birth there was no significant difference in minor withdrawal symptoms and signs, general practitioner or accident and emergency visits between the group who did not receive treatment for withdrawal and the control group. If immediate treatment for withdrawal is not required major symptoms do not subsequently occur with great frequency. Late withdrawal signs were not seen in this study.
对32名母亲服用美沙酮所生婴儿及32名匹配的对照组婴儿进行了研究，以确定母亲使用美沙酮所生婴儿戒断症状持续存在的发生率、时间和频率。12名（37%）婴儿因戒断症状接受了治疗。从出生到开始治疗的中位时间为23小时（范围15 - 64小时），中位治疗时间为6天（范围1 - 22天）。在出生后的前六周，未接受戒断治疗的组与对照组在轻微戒断症状和体征、全科医生就诊或急诊就诊方面没有显著差异。如果不需要立即进行戒断治疗，随后不会频繁出现主要症状。本研究中未观察到晚期戒断症状。
