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活的和死的细胞内细菌在体外对巨噬细胞衍生细胞因子的差异诱导作用。

Differential induction of macrophage-derived cytokines by live and dead intracellular bacteria in vitro.

作者信息

Zhan Y, Cheers C

机构信息

Department of Microbiology, University of Melbourne, Parkville, Victoria, Australia.

出版信息

Infect Immun. 1995 Feb;63(2):720-3. doi: 10.1128/iai.63.2.720-723.1995.

Abstract

Marked differences in the abilities of living and heat-killed Brucella abortus and Listeria monocytogenes organisms to induce production of tumor necrosis factor alpha by in vitro-cultured macrophages were observed. Interleukin-1 and interleukin-6 appeared to be under different control. The results are discussed in relation to the induction of gamma interferon-producing Th1 cells and acquired cellular resistance to infection by living vaccines but not killed vaccines.

摘要

观察到活的和热灭活的流产布鲁氏菌及单核细胞增生李斯特菌诱导体外培养巨噬细胞产生肿瘤坏死因子α的能力存在显著差异。白细胞介素-1和白细胞介素-6似乎受不同的调控。结合产生γ干扰素的Th1细胞的诱导以及活疫苗而非灭活疫苗诱导的获得性细胞抗感染能力对结果进行了讨论。

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