Willkens R F, Segre E J
Arthritis Rheum. 1976 Jul-Aug;19(4):677-82. doi: 10.1002/1529-0131(197607/08)19:4<677::aid-art1780190404>3.0.co;2-a.
Thirty-six patients with rheumatoid arthritis were studied to determine the effectiveness and safety of combined therapy with naproxen and aspirin. An 8-week double-blind crossover trial was performed in which naproxen and placebo were administered on a background of constant-dose aspirin. Combination therapy was demonstrated to be more effective than aspirin alone. Tolerance of the two regimens was comparable.
对36名类风湿性关节炎患者进行了研究，以确定萘普生和阿司匹林联合治疗的有效性和安全性。进行了一项为期8周的双盲交叉试验，在恒定剂量阿司匹林的基础上给予萘普生和安慰剂。结果表明，联合治疗比单独使用阿司匹林更有效。两种治疗方案的耐受性相当。
