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[肺癌患者血液中脂质过氧化及磷脂谱的变化]

[Changes in lipid peroxidation and phospholipid spectrum of blood in patients with lung cancer].

作者信息

Khyshiktuev B S, Khyshiktueva N A, Ivanov V N, Darenskaia S D

出版信息

Vopr Onkol. 1993;39(7-12):288-91.

PMID:7825299
Abstract

The parameters of the lipid peroxidation - antioxidants system, phospholipid profile, erythrocytes and blood plasma of 47 patients with lung cancer were studied. Serious disturbances in phospholipids profile in cases of central and peripheral lung cancer were identified. They included a decreased phosphatidycholine level, accumulation of lysophospholipids and appearance of phosphatidyglyceral fraction in blood plasma. Those shifts occurred alongside with enhanced lipid peroxidation and a deficit of antioxidation protection factors.

摘要

对47例肺癌患者的脂质过氧化-抗氧化系统参数、磷脂谱、红细胞和血浆进行了研究。发现中央型和周围型肺癌患者的磷脂谱存在严重紊乱。包括血浆中磷脂酰胆碱水平降低、溶血磷脂积累以及磷脂酰甘油组分出现。这些变化伴随着脂质过氧化增强和抗氧化保护因子缺乏。

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PLoS One. 2021 Apr 23;16(4):e0249648. doi: 10.1371/journal.pone.0249648. eCollection 2021.