Zurabian V A, Markovskaia E I, Popova G O, Mikhalevich R V, Makarovskaia L N
Antibiot Khimioter. 1994 Apr;39(4):29-31.
The influence of aminoglycosides (gentamicin, sisomicin and amikacin), cephalosporins (cefotaxime, ceftazidime and cefazolin) and semisynthetic penicillins (ampicillin and azlocillin) on the vital activity of macrophage-absorbed plague microbe was studied in a model of peritoneal macrophages of albino mice. It was shown that the aminoglycosides and betalactams added to the medium for the cultivation of the macrophages with the absorbed cells of the plaque microbe lowered the intensity of the plague microbe multiplication and promoted the phagocytosis completion when exposed for a prolonged time (24 hours). When the influence was body-mediated (albino mice), even a single administration of the antibiotics was sufficient to retard the vital activity of the macrophage-absorbed plague microbe during the first 6 hours of the observation period. It was also shown that the aminoglycosides were more active than the betalactams.
在白化小鼠腹腔巨噬细胞模型中，研究了氨基糖苷类抗生素（庆大霉素、西索米星和阿米卡星）、头孢菌素（头孢噻肟、头孢他啶和头孢唑林）以及半合成青霉素（氨苄西林和阿洛西林）对巨噬细胞吞噬的鼠疫杆菌生命活动的影响。结果表明，在含有被鼠疫杆菌细胞吸附的巨噬细胞的培养基中添加氨基糖苷类抗生素和β-内酰胺类抗生素，长时间（24小时）作用可降低鼠疫杆菌的繁殖强度，并促进吞噬作用的完成。当通过机体介导（白化小鼠）时，即使单次给予抗生素也足以在观察期的前6小时内抑制巨噬细胞吞噬的鼠疫杆菌的生命活动。研究还表明，氨基糖苷类抗生素比β-内酰胺类抗生素更具活性。
