Brouwers P, DeCarli C, Civitello L, Moss H, Wolters P, Pizzo P
Pediatric Branch, National Cancer Institute, Bethesda, Md.
Arch Neurol. 1995 Jan;52(1):39-44. doi: 10.1001/archneur.1995.00540250043011.
To evaluate the clinical significance of computed tomographic brain scan abnormalities observed in children with symptomatic human immunodeficiency virus disease.
Eighty-seven previously untreated children with symptomatic human immunodeficiency virus type 1 disease.
General levels of cognitive functioning, obtained from age-appropriate intelligence tests, and social-emotional behavior were correlated with computed tomographic brain scan abnormality ratings.
A significant relation between computed tomographic brain scan abnormalities and cognitive dysfunction as well as aberrant behavior was found, which appeared stronger in (younger) vertically infected children compared with transfusion-infected patients. Calcifications, independent from the degree of brain atrophy, were associated with significantly greater delays in neurocognitive development.
Computed tomographic brain scan abnormalities, even when mild, were of clinical significance, suggesting that human immunodeficiency virus-associated central nervous system compromise is a continuous process and that scans may be helpful at baseline in defining patients at risk and for monitoring them during therapy.
评估有症状的人类免疫缺陷病毒病患儿脑部计算机断层扫描异常的临床意义。
87名先前未接受治疗的有症状的1型人类免疫缺陷病毒病患儿。
通过适合年龄的智力测试得出的一般认知功能水平以及社会情感行为与脑部计算机断层扫描异常评级相关。
发现脑部计算机断层扫描异常与认知功能障碍以及异常行为之间存在显著关联，与输血感染患者相比，这种关联在（年龄较小的）垂直感染儿童中似乎更强。钙化与脑萎缩程度无关，与神经认知发育的显著延迟有关。
脑部计算机断层扫描异常即使很轻微也具有临床意义，这表明人类免疫缺陷病毒相关的中枢神经系统损害是一个持续的过程，扫描可能有助于在基线时确定有风险的患者并在治疗期间对他们进行监测。
