Uemura Y, Tokunaga M, Arikawa J, Yamamoto N, Hamasaki Y, Tanaka S, Sato E, Land C E
Department of Pathology, Kagoshima City Hospital, Japan.
Cancer Epidemiol Biomarkers Prev. 1994 Oct-Nov;3(7):607-11.
Epstein-Barr virus (EBV) involvement in gastric cancer is demonstrated by uniform presence of viral RNA in carcinoma cells as detected by EBV-encoded small RNA in situ hybridization, monoclonal proliferation of EBV-infected carcinoma cells, and elevated antibodies. Our review of selected early gastric cancers found that 46 of 49 EBV-positive lesions (94%) but only four of 97 EBV-negative lesions (4%) conformed to a unique morphology, in which carcinoma cells formed lace patterns of branching and/or anastomosing structures with lymphocytic infiltration in and around the carcinoma nests in the mucosa. We conclude that EBV-related gastric carcinoma has a distinct and characteristic morphology in the early stage of development, and this lace pattern is a biomarker of EBV involvement in early gastric cancer.
通过EB病毒编码的小RNA原位杂交检测到癌细胞中病毒RNA的一致存在、EB病毒感染的癌细胞的单克隆增殖以及抗体升高，证明了爱泼斯坦-巴尔病毒（EBV）与胃癌有关。我们对选定的早期胃癌进行的回顾发现，49个EBV阳性病变中有46个（94%），但97个EBV阴性病变中只有4个（4%）符合独特的形态，即癌细胞形成分支和/或吻合结构的花边图案，黏膜癌巢内及周围有淋巴细胞浸润。我们得出结论，EBV相关胃癌在发展早期具有独特的特征形态，这种花边图案是EBV参与早期胃癌的生物标志物。
