Ojima H, Fukuda T, Nakajima T, Takenoshita S, Nagamachi Y
First Department of Surgery, Gunma University School of Medicine, Japan.
Anticancer Res. 1996 Sep-Oct;16(5B):3081-4.
We investigated the clinicopathological characteristics of EBV-associated gastric cancers among poorly differentiated gastric adenocarcinomas. A total of 412 patients with poorly differentiated gastric adenocarcinoma were studied for Epstein-Barr virus (EBV) infection by in situ hybridization for EBV-encoded small RNA. EBV genomes were detected in the tumor cell nuclei of 83 gastric cancers (20.1%). Of these EBV-positive cancers, 60 were histologically classified as gastric carcinoma with lymphoid stroma. Comparing various clinicopathological data with EBV status in gastric cancers revealed a significantly large discrepancy between the clinical and pathological lymph node evaluation of the EBV-positive cancers as compared with that of EBV-negative cancers. These results indicated that a strong host immune reaction occurs in the regional lymph nodes of EBV-associated gastric cancers, and that surgeons should be warned against clinically overestimating the stage of EBV-associated gastric cancer.
我们研究了低分化胃腺癌中EBV相关胃癌的临床病理特征。对412例低分化胃腺癌患者进行了原位杂交检测爱泼斯坦-巴尔病毒（EBV）编码的小RNA，以研究EBV感染情况。在83例胃癌（20.1%）的肿瘤细胞核中检测到EBV基因组。在这些EBV阳性癌中，60例在组织学上被分类为伴有淋巴间质的胃癌。将各种临床病理数据与胃癌中的EBV状态进行比较，发现与EBV阴性癌相比，EBV阳性癌的临床和病理淋巴结评估之间存在显著差异。这些结果表明，EBV相关胃癌的区域淋巴结中发生了强烈的宿主免疫反应，并且应提醒外科医生注意临床上对EBV相关胃癌分期的高估。
