Kricker A, Armstrong B K, English D R, Heenan P J
International Agency for Research on Cancer, Lyon, France.
Int J Cancer. 1995 Feb 8;60(4):489-94. doi: 10.1002/ijc.2910600411.
Our report deals with the relationship of pattern and timing of sun exposure to basal cell carcinoma (BCC) in a population-based case-control study conducted in Western Australia in 1988. The main measure of intermittent exposure was based on the amount of exposure on non-working days relative to that over the whole week. Outdoor recreational activities, holidays and sunburn were also considered to be markers of intermittent exposure. We observed a statistically significant increase in risk of BCC with increasing proportion of weekly sun exposure obtained at the weekend, especially in late teenage (OR = 3.9, 95% CI 1.9-7.8 for maximum intermittency of exposure), exposure of the site of skin cancer during holidays (OR = 1.9, 95% CI 1.1-3.1 for the highest exposure quarter) and sunburn to the site (ORs of 1.8 for 3-10 and 1.5 for 11+ sunburns in a lifetime). Risk of BCC increased substantially with increasing intermittency in poor tanners but not at all in good tanners. Our data suggest that a particular amount of sun exposure delivered in infrequent, probably intense increments will increase risk of BCC more than a similar dose delivered more continuously over the same total period of time.
在1988年于西澳大利亚开展的一项基于人群的病例对照研究中，我们的报告探讨了日光暴露模式和时间与基底细胞癌（BCC）之间的关系。间歇性暴露的主要衡量指标基于非工作日的暴露量相对于整个星期的暴露量。户外娱乐活动、假期和晒伤也被视为间歇性暴露的标志。我们观察到，随着周末获得的每周日光暴露比例增加，基底细胞癌风险在统计学上显著增加，尤其是在青少年后期（暴露最大间歇性时，比值比=3.9，95%置信区间1.9 - 7.8），假期期间皮肤癌部位的暴露（最高暴露季度时，比值比=1.9，95%置信区间1.1 - 3.1）以及该部位的晒伤（一生中3 - 10次晒伤时比值比为1.8，11次及以上晒伤时比值比为1.5）。在肤色浅的人中，基底细胞癌风险随着间歇性增加而大幅上升，但在肤色深的人中则完全没有变化。我们的数据表明，在不频繁、可能强度较大的增量中给予特定量的日光暴露，比在相同总时间段内更持续地给予相似剂量会增加更多基底细胞癌风险。
