Kricker A, Armstrong B K, English D R, Heenan P J
International Agency for Research on Cancer, Lyon, France.
Int J Cancer. 1995 Feb 8;60(4):482-8. doi: 10.1002/ijc.2910600410.
A population-based case-control study of sun exposure and basal cell carcinoma (BCC) was conducted in Western Australia in 1988. Its aim was to examine the relationship between risk of BCC and the amount and pattern of sun exposure. This report deals with amount of exposure. The odds ratios (ORs) for BCC on the head and neck and limbs decreased with increasing total exposure, whereas the opposite was observed for BCC on the less heavily exposed trunk, with the highest OR in those with the greatest exposure. In an analysis of all body sites together in which the total hours of exposure to the specific site was treated as a continuous variable, an initial rise in risk of BCC was seen with a peak OR of 1.4 at about 35,000 hr of exposure, followed by a fall. In contrast to these site-specific patterns, lifetime accumulated sun exposure of the whole body showed no appreciable association with BCC either in total or for working days only. Risk of BCC was positively associated with lifetime exposure on non-working days, however, with an OR for higher than baseline categories of around 1.7. There was a significant interaction between ability to tan and total and occupational sun exposure. Risk increased with increasing exposure in those who tanned well but not in those who tanned poorly. This pattern is consistent with other observations which indicate that beyond a certain level of sun exposure risk of BCC does not increase further.
1988年在西澳大利亚进行了一项基于人群的日光暴露与基底细胞癌（BCC）的病例对照研究。其目的是研究BCC风险与日光暴露量及暴露模式之间的关系。本报告涉及暴露量。头颈部和四肢BCC的比值比（OR）随总暴露量增加而降低，而在暴露较少的躯干上的BCC则观察到相反情况，暴露量最大者的OR最高。在一项将特定部位的总暴露小时数作为连续变量的所有身体部位综合分析中，BCC风险最初上升，暴露约35000小时时OR峰值为1.4，随后下降。与这些特定部位模式不同，全身的终生累积日光暴露无论总体还是仅工作日均与BCC无明显关联。然而，BCC风险与非工作日的终生暴露呈正相关，高于基线类别的OR约为1.7。晒黑能力与总日光暴露和职业性日光暴露之间存在显著交互作用。晒黑良好者的风险随暴露增加而增加，而晒黑不佳者则不然。这种模式与其他观察结果一致，即超过一定水平的日光暴露后，BCC风险不会进一步增加。
