来自海洋海绵动物瘤状扁海绵的新型细胞毒性过氧内酯。

New cytotoxic peroxylactones from the marine sponge, Plakinastrella onkodes.

作者信息

Horton P A, Longley R E, Kelly-Borges M, McConnell O J, Ballas L M

机构信息

Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc., Ft. Pierce, Florida 34946.

出版信息

J Nat Prod. 1994 Oct;57(10):1374-81. doi: 10.1021/np50112a006.

DOI:10.1021/np50112a006

PMID:7807122

Abstract

Three new peroxylactones, plakortolides B [6], C [7], and D [8], and a new peroxy ester, epiplakinic acid E methyl ester [9], were isolated and characterized from a previously unstudied marine sponge, Plakinastrella onkodes. A mixture of steroidal peroxides was also found in this organism. Plakortolides B [6] and D [8], and epiplakinic acid E methyl ester [9], were evaluated for biological activity and found to show cytotoxicity against the A549 human lung carcinoma and P388 murine leukemia cell lines, and to effect adhesion in an assay employing the EL-4.IL-2 cell line, which correlates with signal transduction activity.

摘要

从一种此前未被研究过的海洋海绵——瘤状扁海绵（Plakinastrella onkodes）中分离并鉴定出了三种新的过氧内酯，即扁海绵内酯B[6]、C[7]和D[8]，以及一种新的过氧酯，表 plakinic 酸E甲酯[9]。在这种生物中还发现了一种甾体过氧化物混合物。对扁海绵内酯B[6]和D[8]以及表plakinic酸E甲酯[9]进行了生物活性评估，发现它们对A549人肺癌细胞系和P388小鼠白血病细胞系具有细胞毒性，并且在使用EL-4.IL-2细胞系的实验中影响黏附，这与信号转导活性相关。